A "box of tissues" is a common phrase that refers to a package containing several sheets of paper for wiping or blowing one's nose, commonly used to alleviate congestion or clear mucus from the nose.
Sentences with «box of tissues»
There are three boxes of tissue on my desk. (hlaw.ca)
We'll be there for date night, box of tissues in hand. (csmonitor.com)
For the price of admission to this one they ought to give you an entire box of tissues — they can come in handy here. (digitalshortbread.com)